Pyridoxal-5-Phosphate (P5P) – B6 is critical for a healthy immune system; it helps produce proteins and antibodies that regulate your immunity and increase your white blood cell count. B6 is also necessary for making serotonin and helps balance dopamine and norepinephrine. We use P5P instead of vitamin B6 because P5P is the bio-active form of B6 and some people have trouble converting B6 into P5P. B vitamins are water-soluble and aren’t stored in your body, so they need to be constantly replenished. Many substances can prevent B6 from being absorbed, including alcohol, coffee, birth control pills, food coloring and more. In addition, B vitamins are delicate and are easily destroyed by microwaving, freezing, canning and heat.
Quatrefolic (B9/Folic Acid) – Folate helps produce antibodies that support your immune system and low levels can lead to a decrease in resistance to infections. In addition, low levels of folate/folic acid are linked to higher levels of homocysteine, a protein that causes inflammation throughout your body. Quatrefolic is a Registered Trademark of Gnosis S.p.A, U.S. Patent No. 7,947,662. It is a natural, concentrated form of vitamin B9/folic acid that is found in high-quality supplements. Quatrefolic is easily and quickly absorbed because it is already in a form that your body can use. Other forms of folic acid are not biologically active and need to be converted multiple times in your body before they can be used. Many medications decrease the level of folate/folic acid, including methotrexate, phenytoin, trimethoprim and birth control pills.
Vitamin D3 (Cholecalciferol) – Vitamin D3 helps regulate the growth of immune system cells, including proteins that directly kill bacteria. Studies show that people with low levels of vitamin D are at a higher risk of developing infections. We use D3 instead of D2 (ergocalciferol) because D3 is about 87% more potent in raising and maintaining vitamin D concentrations than D2, and is also converted into its active form 500% faster than D2. Vitamin D is one of the most common vitamin deficiencies in the United States. It is estimated that 70% of the US population is not getting adequate D. Another study found that only 10% of the US population had therapeutic levels of vitamin D3 in their systems. Adequate levels will also help elevate your mood, and improve your memory and other cognitive abilities. It can take several months for vitamin D supplementation to normalize levels.
Zinc Orotate – Zinc is a mineral and antioxidant that helps control infections by limiting your immune system response which prevents excessive inflammation. Zinc also fights off bacteria and viruses that are overwhelming your body’s defenses. We use zinc orotate because it passes through cell membranes easier than other types of zinc; therefore there are higher concentrations of zinc in your tissues. Zinc sulfate, zinc gluconate, and zinc oxide are popular but not bio-available; very little is absorbed by your body. Zinc is required to utilize P5P (B6) and is depleted by alcohol consumption. If you eat processed foods or very little meat, a zinc supplement is a good idea. Zinc deficiency affects an estimated 40% of the elderly in the United States. Zinc is also an excellent antioxidant and will protect your cells from free radical damage, so it is also included in our Antioxidant Formula.
Vitamin E (d-alpha tocopherol) – Vitamin E is a fat-soluble, powerful antioxidant that helps your body fight off infections by creating a protein that destroys bacteria and viruses. We use d-alpha tocopherol because it is better absorbed than the synthetic form, dl-alpha tocopherol.
Selenomethionine and Methyl L-Selenocysteine – Selenium is a mineral found in soil, water and some food. It helps support a strong immune system and has antiviral effects. Many supplements use sodium selenite which is inorganic, synthetic, and poorly retained; it is quickly filtered out by the kidneys and excreted in urine. The selenium types we use are naturally occurring and organic, therefore they are better retained and utilized by your body. Alcohol consumption and GI problems can lower selenium levels.
Beta Carotene – A red-orange pigment and plant-derived antioxidant that is converted to active vitamin A (retinol) in your body. Beta-carotene needs zinc to work properly. Beta-carotene is a strong antioxidant and is needed for healthy mucus membranes and good immunity; it is crucial for helping your skin and mucous membranes repel bacteria and viruses. Avoid retinyl palmitate or retinyl acetate which can build up and cause vitamin A toxicity. Beta-carotene does not cause serious health risks because your body only converts as much as it needs. Many supplements use synthetic vitamin A which cannot be used by your body so it builds up and can become toxic. Beta carotene is the bio-available form and has an antioxidant effect that helps strengthen your immune system against infection by ensuring your natural killer cells work properly. Smokers should not take beta-carotene or vitamin E because there is a slightly higher risk of lung cancer.
Vitamin C – A water-soluble vitamin and an excellent antioxidant that stimulates the production of white blood cells that attack bacteria. It also increases levels of antibodies which destroy foreign pathogens. Vitamin C is also extremely beneficial for eye health, which is why it is included in our Vision Formula. In addition, vitamin C protects your brain cells from free radical damage and is included in our Memory/Cognitive Function Formula, as well.
L-Threonine – L-threonine helps produce antibodies that strengthen the immune system. The thymus gland needs L-threonine to fight infectious microorganisms and cancer cells. Only the L-threonine form is biologically active for humans and is found in nature. L-threonine is an essential amino acid; it cannot be made by our bodies and must be obtained from our diets. Best sources are animal proteins so strict vegetarians may need to supplement.
Bacillus Coagulans Probiotic – We have included a shelf-stable probiotic that does not require refrigeration because recent research has made it clear that beneficial bacteria in our bodies are incredibly important for our mental health, immune system, and overall health. Surprisingly, the good bacteria in your GI tract makes up 70-80 percent of your entire immune system. Probiotics help restore the integrity of the intestinal wall, which is a barrier to pathogens entering the blood stream from the gastrointestinal tract. Probiotics modulate immune functions by interacting with receptors on intestinal epithelial cells and other immune cells.
Magnesium Bisglycinate – Magnesium is important for the synthesis of glutathione, a powerful antioxidant which protects and strengthens your immune system. Magnesium is also required for the proliferation of lymphocytes which destroy bacteria and viruses. We use bisglycinate because it is much more bio-active than other types of magnesium. It is four times more effective than citrate forms of magnesium. After vitamin D, magnesium deficiency is the second most common nutrient deficiency in developed countries. In the U.S. magnesium deficiency can be due to our consumption of processed foods and the depletion of magnesium from agricultural soil and water. Caffeine and alcohol consumption also deplete magnesium. It can take three months to see results of magnesium supplementation.